Principal Investigator
Principal Investigator
Principal Investigator
Principal Investigator
I come from the island of Corfu, Greece. I studied Cell and Molecular Biology at the University of Kent in Canterbury, UK. I then moved to the University of Ioannina, Greece, for my PhD, working on epigenetic regulation during mitosis. During my PhD, I came to appreciate the critical role of chromatin structure in gene regulation and became fascinated by visualizing these processes in cells using multispectral imaging. I also recognized the limitations of conventional fluorescence microscopy for exploring nuclear ultrastructure, which requires sub-diffraction imaging. This led me to the lab of Thomas Cremer at LMU Munich for my postdoc, where I worked on super-resolution microscopy of nuclear landscapes using one of the first 3D-SIM systems worldwide. I optimized imaging and FISH techniques, focusing on the challenging stem cell nucleus, CRISPR editing tools, and quantitative image analysis pipelines. I later moved to UCLA, joining Kathrin Plath’s lab as an associate project scientist to continue work on X-inactivation. My research delivered key insights into epigenome organization in early embryonic development and the process of X-inactivation. I identified the formation of approximately 50 nanosized supramolecular complexes (SMACs) that silence an entire 170 Mb chromosome. In 2023, I opened my lab at the Institute of Structural and Chemical Biology, University of Leicester, where we continue to investigate epigenome organization and function in early development.
I studied Molecular Biology and Genetics at the Aristotle University of Thessaloniki and gained experience in biochemistry and clinical Immunology during internships at the University of Athens Medical School. I then expanded my expertise in non-coding RNA biology and protein biosignalling by completing an MRes in Biological Sciences at the University of Manchester.
My BBSRC-DTP-funded PhD in the Delneri lab at the University of Manchester focused on mitochondrial biology, investigating their role in eukaryotic evolution and cellular health through quantitative multispectral imaging. As a postdoctoral researcher, I applied this expertise in synthetic biology and biotechnology, contributing to two multi-centre EU H2020 and one industry-funded project.
I have joined the Markaki lab as a Daphne Jackson Fellow supported by ME Research UK and the MRC. My current research investigates mitochondrial function in ME/CFS using genome editing, omics, super-resolution imaging and stem cell biology approaches.
Fun fact: I enjoy DIY art and have set up a small studio for crafting.
Daphne Jackson Fellow
Postdoc
I'm originally from Costa Rica where I got a degree in Chemistry from the University of Costa Rica. I then obtained a M.Sc. in Chemistry from the Weizmann Institute in Israel and a Ph.D. in Structural Biology from the Magnetic Resonance Centre in Italy.
During the Ph.D., my research was focused on the study of protein interactions using Nuclear Magnetic Resonance Spectroscopy on isotopically enriched samples. I joined the Markaki lab in 2025 as a part of the AMBER consortium, funded by an MSCA COFUND fellowship, where I apply an array of biophysical, cellular and structural biology techniques for the structural characterization of multi-protein Supramolecular Complexes, formed around Xist-RNA and known to play a crucial role in X-Chromosome Inactivation.
Fun fact: I like off-the-beaten-path destinations.
After finishing my Biochemistry BSc degree at the University of Leicester, I enrolled in the MRC AIM DTP program to do a PhD in the John Schwabe lab. My project involved investigating HDAC complex function via CRISPR-Cas9 tagged protein degradation and multi-omic study of transcriptional and acetylomic changes. At the end of the PhD project, I followed my interest in epigenetics and joined the Markaki lab as a Research Assistant to apply CRISPR-Cas9 and multi-omic techniques to study the process of X chromosome inactivation in human development.
Fun fact: I enjoy traveling, experiencing new cultures and writing fantasy stories.
Research Assistant
PhD student
I’m originally from Athens, Greece but I completed secondary school in Switzerland. After earning my Bachelor’s degree in biomedical science from the University of Birmingham, I worked as a research assistant at the University of Leicester under Professor Thomas Schalch, investigating the molecular mechanisms behind heterochromatin formation. Currently, I’m an MIBTP DTP student in the Markaki lab, where I’m applying single-molecule localisation techniques to study biomolecular assembly in gene regulation.
Fun fact: I used to be on the Greek national figure skating team.
Before coming to Leicester, I completed an integrated Masters in Biochemistry and Genetics at the University of Sheffield in which I studied the involvement of enhancer RNAs in gene regulation using CRISPR-Cas13 knockdown. Currently, I am a first year PhD student in the Schwabe and Markaki labs where I am using mouse embryonic stem cells as a model system and quantitative advanced imaging to investigate the regulation of heterochromatin and specifically X-chromosome inactivation in development.
Fun fact: I like to draw imaginery places in my lab book.
PhD student
PhD student
Before starting my PhD at Leicester I studied Biochemistry at York, where I undertook a yearlong project with the Avestro lab creating water soluble intercalators by organic synthesis. I then moved to Birmingham to study Molecular Biotechnology. Here I used solid state peptide synthesis to create novel lanthanide ligands with the Peacock lab. I am funded by the AIM MRC DTP and in the Markaki lab I work on the link between initiation and maintenance of X-linked gene silencing in health, ageing and immunity using super-resolution microscopy.
Fun Fact: I’m a massive animal person and have 16 pets- ranging from dogs and cats to horses and ducks.
I studied biochemistry at Kingston university and in this time completed an internship in Chicago providing psychosocial support for cancer patients. From there I went on to do a Master’s degree at Queen Mary University of London, completing a project investigating the link between post-translational modifications of microtubules and DNA damage response. Now pursuing a PhD within the Markaki lab, I am exploring the roles of Histone deacetylation in human embryonic development using stem cells as a model system.
Fun fact: I play the cornet.
PhD student
MSc student
I hold a Bachelor’s degree in medical laboratory technology from Father Muller Medical College, India, where my research journey began with a survey on the Awareness of Digital Imaging and Telepathology among Laboratory Professionals. Driven by my passion for cancer detection and treatment, I pursued an MSc in Cancer Cell and Molecular Biology at the University of Leicester. For my Master’s research project, I joined the Markaki lab, delving into epigenetics of early development using advanced imaging and genome editing systems.
Fun fact: I love elevating spaces with aesthetic lights and art, and dancing is my ultimate form of self-expression and joy!
Before my current master's program at University of Leicester, I earned my BSc in Medical Biochemistry at the same university. My research interests lie in molecular biology, particularly disease progression and targeted therapies. During my undergrad, I worked on DNA origami-based nanostructures and got the opportunity of exploring a project on rolling cell adhesion at University of British Columbia.
Fun fact: I enjoy lazy mornings—preferably with a good cup of tea and no rushed plans!
MSc student