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Principal Investigator
I come from the island of Corfu, Greece. I studied Cell and Molecular Biology at the University of Kent at Canterbury, UK. I then moved to the BRI-FORTH and the University of Ioannina, Greece for my PhD where I worked on epigenetic regulation during mitosis with Spyros Georgatos. During my PhD I started to understand the critical role that chromatin structure plays in gene regulation while I was fascinated by visualizing these processes within cells with multisprectral imaging. I also began to realize the limitations of conventional fluorescence microscopy to go deeper into nuclear ultrastructure that requires sub-diffraction imaging. This took me to the labs of Thomas Cremer and Heinrich Leonhardt at the LMU in Munich, Germany for my postdoc. There I worked on super-resolution microscopy of nuclear landscapes -on one of the first 3D-SIM systems in the world! I optimized imaging and FISH techniques focusing on the challenging stem cell nucleus, CRISPR editing tools and quantitative image analysis pipepines. I later move to the US at UCLA to collaborate with Kathrin Plath as an associate project scientist and to continue my work on X-inactivation. My work delivered critical insights into epigenome organization in early embryonic development and particularly the process of X-inactivation. I identified the formation of supramolecular complexes, SMACs and proposed a mechanism with which only ~100 Xist molecules silence an entire 170Mb chromosome. I started in my new role as a PI at the Leicester Institute of Structural and Chemical Biology in November 2022 and my lab opened its doors in August 2023 continuing the quest into epigenome organization and function.
I'm originally from Costa Rica where I got a degree in Chemistry from the University of Costa Rica. I then obtained a M.Sc. in Chemistry from the Weizmann Institute in Israel and a Ph.D. in Structural Biology from the Magnetic Resonance Centre in Italy.
During the Ph.D., my research was focused on the study of protein interactions using Nuclear Magnetic Resonance Spectroscopy on isotopically enriched samples. I joined the Markaki lab in 2025 as a part of the AMBER consortium, funded by an MSCA COFUND fellowship, where I apply an array of biophysical, cellular and structural biology techniques for the structural characterization of multi-protein Supramolecular Complexes, formed around Xist-RNA and known to play a crucial role in X-Chromosome Inactivation.
Fun fact: I like off-the-beaten-path destinations.
Postdoc
Research Assistant
After finishing my Biochemistry BSc degree at the University of Leicester, I enrolled in the MRC AIM DTP program to do a PhD in the John Schwabe lab. My project involved investigating HDAC complex function via CRISPR-Cas9 tagged protein degradation and multi-omic study of transcriptional and acetylomic changes. At the end of the PhD project, I followed my interest in epigenetics and joined the Markaki lab as a Research Assistant to apply CRISPR-Cas9 and multi-omic techniques to study the process of X chromosome inactivation in human development.
Fun fact: I enjoy traveling, experiencing new cultures and writing fantasy stories.
I’m originally from Athens, Greece but I completed secondary school in Switzerland. After earning my Bachelor’s degree in biomedical science from the University of Birmingham, I worked as a research assistant at the University of Leicester under Professor Thomas Schalch, investigating the molecular mechanisms behind heterochromatin formation. Currently, I’m an MIBTP DTP student in the Markaki lab, where I’m applying single-molecule localisation techniques to study biomolecular assembly in gene regulation.
Fun fact: I used to be on the Greek national figure skating team.
PhD student
PhD student
Before coming to Leicester, I completed an integrated Masters in Biochemistry and Genetics at the University of Sheffield in which I studied the involvement of enhancer RNAs in gene regulation using CRISPR-Cas13 knockdown. Currently, I am a first year PhD student in the Schwabe and Markaki labs where I am using mouse embryonic stem cells as a model system and quantitative advanced imaging to investigate the regulation of heterochromatin and specifically X-chromosome inactivation in development.
Fun fact: I like to draw imaginery places in my lab book.
Before starting my PhD at Leicester I studied Biochemistry at York, where I undertook a yearlong project with the Avestro lab creating water soluble intercalators by organic synthesis. I then moved to Birmingham to study Molecular Biotechnology. Here I used solid state peptide synthesis to create novel lanthanide ligands with the Peacock lab. I am funded by the AIM MRC DTP and in the Markaki lab I work on the link between initiation and maintenance of X-linked gene silencing in health, ageing and immunity using super-resolution microscopy.
Fun Fact: I’m a massive animal person and have 16 pets- ranging from dogs and cats to horses and ducks.
PhD student
PhD student
I studied biochemistry at Kingston university and in this time completed an internship in Chicago providing psychosocial support for cancer patients. From there I went on to do a Master’s degree at Queen Mary University of London, completing a project investigating the link between post-translational modifications of microtubules and DNA damage response. Now pursuing a PhD within the Markaki lab, I am exploring the roles of Histone deacetylation in human embryonic development using stem cells as a model system.
Fun fact: I play the cornet.
I hold a Bachelor’s degree in medical laboratory technology from Father Muller Medical College, India, where my research journey began with a survey on the Awareness of Digital Imaging and Telepathology among Laboratory Professionals. Driven by my passion for cancer detection and treatment, I pursued an MSc in Cancer Cell and Molecular Biology at the University of Leicester. For my Master’s research project, I joined the Markaki lab, delving into epigenetics of early development using advanced imaging and genome editing systems.
Fun fact: I love elevating spaces with aesthetic lights and art, and dancing is my ultimate form of self-expression and joy!
MSc student
MSc student
Before my current master's program at University of Leicester, I earned my BSc in Medical Biochemistry at the same university. My research interests lie in molecular biology, particularly disease progression and targeted therapies. During my undergrad, I worked on DNA origami-based nanostructures and got the opportunity of exploring a project on rolling cell adhesion at University of British Columbia.
Fun fact: I enjoy lazy mornings—preferably with a good cup of tea and no rushed plans!
BSc student
I'm currently in-between my 2nd and 3rd year of my Biological Sciences BSc programme at the University of Leicester. Throughout my degree, I've delved into various areas such as genomics, neuroscience, and physiology. I have been awarded a Genetics Society studentship to join the Markaki lab that will offer me a unique opportunity to develop my research skills in fluorescence in situ hybridization techniques, imaging and stem cell biology. Looking ahead, my goals lie in continuing my studies in epigenetic regulation, particularly in relation to embryonic development and the ramifications of mechanistic deficiencies.
Fun Fact: I love fantasy and action books!
Having finished my A-levels in London, I chose to continue my degree work in Leicester.
I am currently an undergraduate student at University of Leicester, specialising in Medical Genetics. In the Markaki lab, I am undertaking my third-year project focused on research in histone deacetylases using advanced imaging techniques.
Fun Fact: I enjoy doing art.
BSc student
BSc student
Having lived nearly all my life in Qatar, I decided after secondary school it was time for a change of scenery, so I chose to pursue my education in the UK. I am currently a third-year Medical Bioscience (Genetics) student at the University of Leicester. For my experimental research project, I will be working in the Markaki lab, studying developmental epigenetics using mouse embryonic stem cells and advanced imaging techniques. I’m looking forward to all the knowledge and practical experience I will gain through this project!
Fun Fact: I enjoy watching football and the team I support is Chelsea :,)